Paracetamol is the most widely used over-the-counter and prescription analgesic worldwide.1 It is the first step on the WHO pa.... (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), H341-H371-H372-H373-H411-H402-H412-H302-H315-H317-H319-H335-H225-H301+H311+H331-H370, P210-P260-P280-P301+P310-P311-P301+P312a-P330-P501a-P201-P202-P264-P270-P273-P307+P311-P391-P405-P501-P301+P312+P330-P305+P351+P338-P261, 22-36/37/38-52/53-36/38-40-39/23/24/25-23/24/25-11, 4-(ACETYLAMINO)PHENOXYACETIC ACID ETHYL ESTER, BETA-(4-(ACETYLAMIDO)PHENOXY)PROPANOIC ACID. Administering Acetaminophen (250 mg/kg, orally) to the mice causes significant (p<0.001) liver damage and necrosis of cells as evidenced by the elevated serum hepatic enzymes alanine aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) compared with normal group. After 12 h of Acetaminophen administration, serum samples and liver tissue are collected followed by biochemistry and histological analysis. of acetaminophen was then characterized by using the methods of melting point range and IR spectroscopy. P280-P301 + P312 + P330-P305 + P351 + P338, R22:Harmful if swallowed. Articles of 4-Acetamidophenol are included as well. M, et al. Journals | (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The username will be used as the login user name and retrieve the password, Copyright 2017 © ChemicalBook. The molecule has a planar geometry with 7 carbon atoms and sp2 hybridization. Hinz, B, et al. FASEB J, 2008. Acetaminophen plasma concentrations remaine above the in vitro IC50 for COX-2 for at least 5 h postadministration. Groups III-V: the mice are pretreated with citral at doses of 125, 250, and 500 mg/kg, respectively. The molecule is not available in nature but it is prepared in the laboratory. To analyze autophagic flux, simultaneously with treatments, cells are exposed to lysosomotropic agent Chloroquine at a concentration of 25 μM, to inhibit autophagosome-lysosome fusion[2]. You can also browse global suppliers,vendor,prices,Price,manufacturers of Acetaminophen(103-90-2). check more 4-Acetamidophenol price, Home | (Dahlin, Nelson), Acetaminophen solution 4-Acetamidophenol; Acetaminophen; APAP; Paracetamol; p-Hydroxyacetanilide; Acetaminophen; APAP; p-Hydroxyacetanilide; Paracetamol, 4-Acetamidophenol,4′-Hydroxyacetanilide, 4-Acetamidophenol, N-Acetyl-4-aminophenol, APAP, Acetaminophen, Acetaminophen Related Compound A (15 mg) (4- Acetaminophen Molecular. 1.0mg/mL in methanol, ampule of 1mL, certified reference material, Acetaminophen It is used for the treatment of arthritis as well. R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . Uchida NS, et al. 2017 Apr 6;8:594. dust mask type N95 (US);Eyeshields;Gloves, 4-13-00-01091 (Beilstein Handbook Reference). Initial dose of acetylcysteine is 140 mg/kg, add 70 mg/kg every 4 h, 17 times totally. The temperature should be greater than 70 degree Celsius when preparing this compound. 4-Acetamidophenol Revision Date 18-Jan-2018 Melting Point/Range 168 - 172 °C / 334.4 - 341.6 °F Boiling Point/Range No information available Flash Point No information available Evaporation Rate Not applicable Flammability (solid,gas) No information available Flammability or explosive limits Upper No data available Lower No data available Vapor Pressure No information available 52(7) , 590-5, (2014). This is a raw material that helps in preparing several other useful medicines. R36/37/38:Irritating to eyes, respiratory system and skin . Mice[3] Male Swiss mice (30-40 g) are used. About Us | When combined with the antiviral drug, zidovudine, it can increase the toxicity. After taking this product, patients should immediately stop taking medicine when symptoms of erythema or edema occur. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. Intake: configure acetylcysteine into a 5% solution or add in triple drinks and take after shaking well to avoid fetid odors and irritations. 2017;2017:1796209. Product Classification | Similar to Aspirin, it was first synthesized in 1877 by Harmon but it was not used till 1893. Dini? Front Microbiol. The formula for this compound is C8H9NO2 and its extended formula is HOC6H4NHCOCH3 with a molecular weight of 151.165 g mol-1. The interferences of diagnosis: ① Glucose measurement, falsely low values are measured by glucose oxidase/peroxidase methods, but no effect occurs when measured by hexokinase /6-dehydrogenase methods; ② Assays for uric acid of serum, falsely high values are measured by phosphotungstic acid method; ③ Determination of urinary 5-hydroxyindoleacetic acid (5-HIAA), falsely positive results are obtained in a screening test with nitroso naphthol reagent, but quantitative test is not affected; ④Liver function tests, prothrombin time, serum bilirubin, lactic dehydrogenase and serum aminotransferase can be increased due to high doses or long-term use. Acetaminophen is paracetamol that is generally used as anti-inflammatory medicine and included in the list of essential WHO medicines needed in health systems. Selling Leads | Furthermore, the overall purpose of this experiment was to perform a synthesis reaction between p-aminophenol and acetic anhydride to form pure acetaminophen using various isolation and purification methods. The caregiver should exhort the patient to pay attention to the following things during medication period: ①No drinking, drinking may aggravate the liver toxicity of this product; ②Drink plenty of water to reduce the concentration of drug in renal tubules and reduce the occurrence of “analgesic nephropathy”; ③When taking chewing chips, chew them up; ④No unauthorized use other NSAIDS or compound preparation containing NSAIDS at the same time to avoid increasing the renal toxicity. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Evid Based Complement Alternat Med. 2017 Apr 6;8:594. Chronic alcohol users (three or more drinks daily) should be warned about an increased risk of liver damage or GI bleeding with acetaminophen. It is generally used to reduce pain or fever in children or adults. This product can be passed through the placenta and secreted in milk, so pregnant women and lactating women are not recommended to use. Human hepatoma cell line HepG2 is cultured in low glucose DMEM supplemented with 10% fetal bovine serum (FBS), 100 U/mL Penicillin and 100 μg/mL Streptomycin and 2 mM l-glutamine.
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