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The authors acknowledge several investigators for the information in Table 1, including J Bernakl, S-Y Cheng, G Morreale, L Ng, D Pfaff, M Raff, T Reh, A Rüsch, J Samarut, B Vennsatröm, and F Wondisford. Circ Res 107(12):1470–1482, Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nebivolol combines a potent beta1-AR antagonistic activity with vasodilating properties, thereby providing cardioprotection, as recently demonstrated in the SENIORS trial in heart failure, together with a modulation of peripheral vasoconstriction. It is unclear if these findings represent a group effect of beta2-adrenoceptor agonists or apply to salbutamol only. The beta-1 adrenergic receptor is a G-protein-coupled receptor communicating through the Gs alpha subunit. These receptors are coupled to various G proteins, including Gs and Gi. Oncogene 26(37):5505–5520, Varma SD (1991) Devamanoharan PS hydrogen peroxide in human blood. 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