(\240 )Tj endobj THE MECHANISM OF ACID-CATALYZED DECARBOXYLATION OF PYRROLE-2-CARBOXYLIC ACID: INSIGHTS FROM CLUSTER-CONTINUUM MODEL CALCULATIONS. 0000003261 00000 n -7.55399 0 Td endobj <> The Burden Borne by, Department of Chemistry and the Quantum Theory Project, 2328 New Physics Building, P.O. Both experimental and theoretical research efforts have studied the reaction in different media, and a consensus has been reached regarding the specific acid- and base-catalyzed reaction pathways. <> not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information 1279 0 obj /T1_3 1 Tf 10 0 0 10 109 344.99994 Tm ET Reaction pathway and free energy barrier for urea elimination in aqueous solution. /T1_3 1 Tf (\225\240 )Tj Find more information about Crossref citation counts. endobj 0 g You’ve supercharged your research process with ACS and Mendeley! Kinetic analysis of the equilibrium formation of two-water adducts and its relevance to the choice of reaction barrier. <> <> 0 -8 8 0 380 314.55609 Tm -4.44499 0 Td 1291 0 obj 6`�A�Ni�m@M�~V�HW��O��0#Is��Yu1�ԯ��0�4�yՔG�K��e�qќx��ɐǷ*Myiv�ƣJ5�[~��x�V���h�K"�k�u�=w�K�zqX2��1����>7��. endobj 1284 0 obj Steven H. Overbury, Alexander I. Kolesnikov, Gilbert M. Brown, Zhiyong Zhang, Gokul S. Nair, Robert L. Sacci, Roghayyeh Lotfi, Adri C. T. van Duin. 0 0 1 rg Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. 0000003217 00000 n 0.43151 1 Td 0000005516 00000 n The Hydrolysis of Amides and the Proficiency of Amidohydrolases. <> 0000008209 00000 n /T1_0 1 Tf 0000003443 00000 n endobj /T1_3 1 Tf Information. endobj Reaction pathways and free energy profiles for spontaneous hydrolysis of urea and tetramethylurea: unexpected substituent effects. endobj <> 0000011541 00000 n BT 0000017128 00000 n <> 0000032757 00000 n 0000034324 00000 n 0000008611 00000 n <> Sansón Martín. (Access the most updated version of this article at )Tj )����K��X���ه�f�2Ɇf�>�͠e��v0�R�%�ݲ����.y^.-��6��C��r��#��s Hydrolysis of Amides 11 The hydrolysis of amides is much more difficult compared to that of esters. �3� ��K 0 1.00001 TD endobj ET 0000017550 00000 n -10.78099 0 Td Effect of organic molecules on hydrolysis of peptide bond: A DFT study. (Click here)Tj 1266 0 obj Theoretical Aspects of Hydrolysis of Peptide Bonds by Zinc Metalloenzymes. 0000032693 00000 n This material is available free of charge via the Internet at http://pubs.acs.org. 1281 0 obj <>/ProcSet[/PDF/Text]>>/Type/Page>> ACS members enjoy benefits including 50 free articles a year and reduced priced individual subscription. startxref 2020-11-12T03:47:37-08:00 ( )Tj 1044 0 obj %PDF-1.4 %���� <> 0 g endobj 0000010700 00000 n 0000003580 00000 n Consequently, they require much harsher conditions usually by heating under either acidic or basic conditions for a prolonged period. 0000001670 00000 n system. 1293 0 obj • Learn some of the important properties of condensation polymers, especially the polyamides. 5.22197 1 Td 0000031901 00000 n 1204 0 obj 1294 0 obj 0000028171 00000 n /T1_3 1 Tf 0000003900 00000 n T* (http://www.jbc.org/content/55/2/191.citation.full.ht)Tj (Downloaded from )Tj %PDF-1.4 %���� 0000003489 00000 n /T1_3 1 Tf (accessed free at)Tj Poliana Lima da Silva, Luciana Guimarães, and Josefredo R. Pliego, Jr. . <> endobj 0 0 1 rg <> Nevertheless, for the water reaction, large discrepancies between theoretical and experimental results are found in the literature. (STABILITY OF SURFACE ACTIVE)Tj endobj 1280 0 obj Please contact your library or account administrator. 0 0 m <>stream endstream Václav Navrátil, Vojtěch Klusák, Lubomír Rulíšek. Users are /T1_0 1 Tf The method used here for determining the stability of amides in the living animal consisted in injectiyg them subcutaneously into fasting cats, the urine being analyzed in 24 hour periods as long as the excretion of amide continued.8 ( by guest on November 12, 2020)Tj -3.112 0 Td A quantum chemical study of HOCl-induced transformations of carbamazepine. endobj 0000014686 00000 n 1205 0 obj endobj 0000003823 00000 n [1297 0 R] Files available from the ACS website may be downloaded for personal use only. Find more information on the Altmetric Attention Score and how the score is calculated. 1295 0 obj 10 0 0 10 89 319.99997 Tm 10 0 0 10 89 254.99988 Tm endobj 1287 0 obj Calculation of free-energy curves for the study of hydrolysis reactions in aqueous solution from ab initio potentials and molecular dynamics simulation. 0000001800 00000 n endstream endobj 76 0 obj <> endobj 77 0 obj <> endobj 78 0 obj <>/ColorSpace<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]/ExtGState<>>> endobj 79 0 obj <> endobj 80 0 obj <> endobj 81 0 obj [/Indexed 93 0 R 3 117 0 R] endobj 82 0 obj [/Indexed 93 0 R 255 108 0 R] endobj 83 0 obj [/Indexed 93 0 R 15 110 0 R] endobj 84 0 obj [/Indexed 93 0 R 255 119 0 R] endobj 85 0 obj [/Indexed 93 0 R 110 96 0 R] endobj 86 0 obj [/Indexed 93 0 R 189 112 0 R] endobj 87 0 obj [/Indexed 93 0 R 255 99 0 R] endobj 88 0 obj [/Indexed 93 0 R 111 105 0 R] endobj 89 0 obj <> endobj 90 0 obj <> endobj 91 0 obj <> endobj 92 0 obj <>stream (When this article is cited)Tj Acrobat 4.0 Capture Plug-in for Windows �N�^�~�.���2��D��2*�A�C��I�,?����H�OdFpc� &��&y��Pn endobj x�b```a``Ue`c``�� Ā B�@Q��Ȼ�H``Rff�c�:`�/d�$�z��^��da���d���q��¤����.x走u��d� �@����H�5000 -0.906 0 Td 89 444 m application/pdf endobj <>stream -0.906 0 Td 1132 0 obj Please reconnect. 0000011905 00000 n (This article cites 0 references, 0 of which can be)Tj 1289 0 obj The aim is to investigate the effect of C−N bond twisting and nitrogen pyramidalization on the rate of hydrolysis. Synthetic Models for the Urease Active Site. %%EOF <> BT -0.86 1 Td endobj 1278 0 obj <> 0000013482 00000 n endobj 1276 0 obj )Tj The mechanisms are much like those of ester hydrolysis (Section 18-7A), but the reactions are very much slower, a property of great biological importance (which we will discuss later): 1207 0 obj <> Model systems have been built clustering one and two water molecules with the reactive amide. uuid:9fc0db93-1dd1-11b2-0a00-810000000000 0 0 1 rg 10 0 0 10 120.11996 375 Tm Acid-Catalyzed Reactions of Twisted Amides in Water Solution: Competition between Hydration and Hydrolysis. Bradley P. Morgan, Alexander Muci, Pu-Ping Lu, Xiangping Qian, Todd Tochimoto, Whitney W. Smith, Marc Garard, Erica Kraynack, Scott Collibee, Ion Suehiro, Adam Tomasi, S. Corey Valdez, Wenyue Wang, Hong Jiang, James Hartman, Hector M. Rodriguez, Raja Kawas, Sheila Sylvester, Kathleen A. Elias, Guillermo Godinez, Kenneth Lee, Robert Anderson, Sandra Sueoka, Donghong Xu, Zhengping Wang, Nebojsa Djordjevic, Fady I. Malik, and David J. Morgans, Jr.. 16 7.6 Hydrolysis of Amides The reversibility of this reaction means that an amide can hydrolyze to form an amine and a carboxylic acid. <> 0 0 1 rg 0000003398 00000 n T* (\240 )Tj 1282 0 obj BT xref Your Mendeley pairing has expired. endobj endobj 1290 0 obj The mechanism of alkaline hydrolysis of amides: a comparative computational and experimental study of the hydrolysis of N -methylacetamide, N -methylbenzamide, and acetanilide Mechanism of Acid-Catalyzed Hydrolysis of Formamide from Cluster-Continuum Model Calculations: Concerted versus Stepwise Pathway. BT 1210 0 obj • Learn the important physical properties of the amines and amides. <> endobj You may be able to access through {InstitutionName}. redistribute this material, requesters must process their own requests via the RightsLink permission Min Yao, Wenlong Tu, Xi Chen, Chang-Guo Zhan. Learn More. (http://www.jbc.org/)Tj 0000033557 00000 n 0000017872 00000 n 0000028827 00000 n endobj The hydrolysis of small amides has garnered major attention due to its relevance to peptide hydrolysis, one of the most fundamental reactions of biology. <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> /T1_0 1 Tf You have to login with your ACS ID befor you can login with your Mendeley account.
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